In the Plaza de Armas Arturo Prat, there are a number of bars, restaurants, coffee shops and tourist agencies. The busiest streets are likely to be Eberhard, Bulnes, Baquedano and Blanco Encalada.
The Etherh Aike Craft Village is a bustling area of the town. With 23 local craft shops, you will be sure to find some great trinkets to remember your trip.
The Municipal History museum (Museo Historico Municipal) is the principle museum in Puerto Natales and houses a collection of artifacts dating back to the earliest settlers and detailing the indigenous culture of this part of Patagonia.
If you have the time, it is well worth taking the forest trail to the Serrano Glacier Viewpoint. To get to the beginning of the trail at the Balmaceda Nursery (CONAF), you must take a boat that that goes through the Seno Ultima Esperanza. The hike is around 1.8km and takes approximately 30 minutes to complete.
Lastly, you could head out of town to visit the Cueva del Milodon, a natural cave around 25km outside of Puerto Natales. It's easy to hire a taxi or, if you are feeling more adventurous, a bike!